Apoquel tablets are scored to be halved to ensure that the ingredients are equally distributed. Little PR, King VL, Davis KR, et al. Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. Its an easy and cost-free strategy you can do yourself. Vet Dermatol 2015;26(1):23-30, e7-8. Avoiding Allergies The second option is serum (blood) testing. For dogs weighing between 10 and 14.9 pounds, give of a 5.4 mg tablet twice daily as dosage. This links to a pdf file Storage and Handling : Store at controlled room temperature 20 to 25C (68 . If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control.16, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20 shutterstock.com/Thrithot, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20. Freedom of Information Summary NADA 141-345 Apoquel is sold per tablet in strengths of 3.6 mg, 5.4 mg, or 16 mg. We recommend Platinum Skin and Allergy or Aleira. Assuming you cannot contact your vet: For hives or possible allergic airway disease (heaves), for a 1000 lb horse, give 5-10 tabs of 25mg diphenydramine crushed up and mixed in water and dosed in a syringe orally (by mouth). Give one chewable per month to the dog. Weve also been able to start rehabbing back into work. These and other kinase-inhibiting drugs sometimes work very well to stop the itching. Vet Dermatol 2019;30(2):87-90. Many allergic reactions are evident as a mild case of transient hives. Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. 1. Then reintroduce each, one by one, while monitoring for hives or other signs of allergies. Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. Pasture-associated equine asthma is most prevalent during the summer in the southeastern U.S. but has been reported worldwide. Clenbuterol dilates the airways, and may improve air flow, but it doesn't treat the inflammation associated with the disease. Cost is about $10 per day for the first few weeks of treatment, and may decrease to around $5 per day depending on the horses response. Vet Dermatol 2013;24:48-e12. Collard WT, Hummel BD, Fielder AF, et al. 3. Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). In severely affected horses, we would expect to see lower airway inflammation and airway obstruction, manifesting as increased respiratory effort, frequent coughing, mucous buildup, and exercise intolerance, White says. These inhaled substances can trigger an allergic response that causes narrowing of the airways, mucous secretion, and cough., Luckily, minimizing common allergens in your horses environment could suffice to restore his comfort and breathing. test dose in your pet before long-term use, espe- cially in horses. While oclacitinib is a very effective and fast-acting antipruritic drug, the decision of when to use it depends on various factors. 20. Transdermal applicator that gives easy & accurate dosing every time. Apoquel should not be used in breeding, pregnant, or lactating dogs. Gonzales AJ, Bowman JW, Fici GJ, et al. In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). 29. Pruritus is a common clinical sign in allergic skin diseases. You are encouraged to speak with your prescriber as to the appropriate use of any medication. This gives you the total number of milligrams for the dose for your horse. Its kind of cumbersome, but I have two on it, and they are doing better. Yamaoka K, Saharinen P, Pesu M, et al. Most commonly, horses develop an allergy to the saliva of biting insects (e.g., gnats, black flies, stable flies, horn flies) known as insect bite hypersensitivity (IBH). A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. Im not dealing with food allergies but both the company and the vet did not recommend allergy shots for my mare. Haugh IM, Watson IT, Menter MA. Apoquel Dosing Chart For Dogs Discount Prices on Pet Supplies, Nexgard, Bravecto, Trifexis, Simparica TRIO, Apoquel, and more. These animals require the opposite regimen. Vet Dermatol 2013;24(6):587-597, e141-142. Alternatively, your veterinarian may be able to show you some techniques. This option has somewhat fewer risks than option 1, has a higher initial cost ($1,000 for the nebulizer mask), but a lower monthly cost- $20-$40/month. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Natural Disaster: Are You and Your Horse Ready for Emergency Evacuation? The recommended Apoquel dosage for dogs is 0.18 to 0.27 mg per lb of body weight (0.4-0.6 mg/kg) once a day. Veterinarians are especially wary of administering corticosteroids to allergic horses that suffer from pituitary pars intermedia dysfunction, insulin dysregulation, and/or equine metabolic syndrome, because these conditions are also risk factors for laminitis. @stb its definitely not cheap. Adv Vet Dermatol 2017;8:192-198. 15. Oclacitinib in feline nonflea-, nonfood-induced hypersensitivity dermatitis: results of a small prospective pilot study of client-owned cats. Why Do Some Horses Develop Respiratory EHV-1 and Others EHM? Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. So I think cost becomes dependent on that. Helpful steps you can take include providing full-body fly apparel, applying fly spray liberally, avoiding turnout at dusk and dawn, and using fans in stalls to disrupt insect flying patterns. 22. Option 4 is an oral tablet called Apoquel. 22. Dosage Chart Dexamethasone is a synthetic corticosteroid hormone used to manage inflammation in diseases or conditions in which the immune system has a significant role. Find out more. Vet Dermatol 2016;27(1):22-e7. Thats def not nothing but its not insane. Each dosage is sold per tablet, in 20 count, or 100 count bottles. "Even though the drug is currently labeled for use in dogs (with. We. on various factors. Skin allergies can also cause pruritus (itching) and associated hair loss. Cosgrove SB, Wren JA, Cleaver DM, et al. These might include antihistamines such as cetirizine, which you can buy over the counter as Zyrtec from any drug store or pharmacy, or hydroxyzine, which requires a veterinary prescription. This encourages the natural drainage of irritants, allergens, and bacteria from the airways.. Genome Biol 2004;5(12):253. If the diagnosis is wrong or the medication affects the horse adversely, you could endanger your horse's life. Barns can also have noxious gases from the ammonia in urine. The recommended dosage of Apoquel 3.6mg tablets is 0.18 to 0.27 milligrams per pound of body weight. Insect and pollen season is here. To overcome its delayed effect, cyclosporine is often initially combined with other drugs such as prednisolone to accelerate the anti-inflammatory and antipruritic effects. has been administered by veterinarians to help horses of . Long term itch reduction. 19. Pollen and other plant-based aeroallergens are the source of their distress, and they fare much better inside, Many allergens can cause skin reactions. Apoquel should be administered orally, twice daily for up to 14 days, and then once daily for maintenance therapy. Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. Topical suspension administered in the ear. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. Vet Dermatol 2014;25:153 (abstract). Collard WT, Hummel BD, Fielder AF, et al. 8. Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis. Dr. Patrick Hensel is a 1996 graduate of the University of Bern, Switzerland. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. Also. Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis.5 Oclacitinib is now also an effective option (BOX 1). Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. I hear the result have been spectacular. Therefore, in many of these cases, veterinarians use steroids sparingly, says Fultz, at lower doses than recommended, or they turn to non-steroidal medications. 23. Horse dosing is 5 pills. The dosages of oclacitinib of 1 mg/kg and 2 mg/kg were chosen because the dosages used for dogs (0.4-0.6 mg/kg) were not shown to be very effective in cats [ 18 ], and the higher dosage range of 0.8-1.3 appeared to be more effective in allergic cats [ 22 ]. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. This medication may be a very good option for minis, since the costs will be much lower. I was one of the veterinarians involved in early field trials for Apoquel in horses. One of the things the trials found on using apoquel with horses is that they need a relatively small dose. Then, doses ranging from 0.4 to 1.2 mg/kg body weight once daily. 27. They result in the production of antibodies that block the allergy-causing IgE from recognizing the allergen, thus preventing the associated symptoms.. It definitely makes them more comfortable. I paid $250 for 100 pills (thats 20 5-pill doses). Administer it orally in the mouth of the or mix it in the dog food. Maximizing ventilation when horses are stalled and bedding with low-dust options such as wood byproducts; Purchasing dust- or mold-free hay and wetting, soaking, or steaming it prior to feeding to reduce inhaled particles; and Offering an alternative feed than hay for low-dust options. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? Option 3 is using a nebulizer with dexamethasone and/or other drugs. Comparing Apoquel and Cytopoint. Avoid storing hay in the same barn as sensitive horses, since hay particles and spores can be irritating, even from a distance and even if they are not visible in the air. You can give your dog Apoquel with or without food. Please select your state below. 26. This study showed that pruritus was improved in only 42% of the study population; thus, use of oclacitinib in cats did not seem to be as effective as in dogs.17 A follow-up study was conducted with a higher dose (0.7 to 1.2 mg/kg) and a longer induction period (28 days). Its important to know, however, that some horses can have BOTH types, and will need to managed year-round!What are your treatment and management options? On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is, Recently, we have found that latex, which is everywhere in the horses environmentembedded in riding surfaces and racetracks, for examplemay be associated with severe equine asthma, he says. Join us as we interview leading equine researchers from the University of Kentucky, Problem Solver Series: How to Control Nuisance Birds on Horse Properties. 2022 Zoetis Services LLC. Dexamethasone: EZ Dose Micro Transdermal Gel, Dexamethasone: Twist-a-Dose Transdermal Gel, Discussion Guide for Pet Owners and Veterinarians, Medication Information for Pet and Horse Owners. This content is intended for counseling purposes only. The efficacy and safety of oclacitinib have been assessed in various studies. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. The Janus kinases (Jaks). Depending on the size of a cat and the condition being treated, a veterinarian may elect to alter the dosage. Apoquel is not FDA approved to use twice daily longer than 14 days. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. 1. But the immune system is not a perfect one. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction.11 Little et al compared oclacitinib to cyclosporine. The efficacy and safety of oclacitinib have been assessed in various studies. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. 1,2 For over 30 years, Adequan i.m. Apoquel Dosage in Dogs Apoquel tablets for dogs comes strengths of 3.6mg, 5.4 mg and 16mg of oclacitinib per tablet. U.S. Food and Drug Administration Center for Veterinary Medicine 7500 Standish Place Rockville, MD 20855 www.fda.gov . Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. You may give this medicine with or without food. In the past 5 years, however, oclacitinib (Apoquel; zoetisus.com), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus. Rabies in Animals. We have limited her exposure to the type of grass that she is most allergic to (bermuda), but it is hard to actually remove her exposure to her allergens entirely. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines. But Im not sure how much the long term cost will be yet. I actually have 2 horses now on serum and one I eliminated the food specific allergens from his diet. It is important to address that the use of oclacitinib in cats is off-label, and owners should be informed before using oclacitinib in this species. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. In cats, this medication can cause excitement rather than sedation. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Option 1 is the cheap/easy route, but comes with risks. 29. Merck & Co., Inc., Rahway, NJ, USA (known as MSD outside of the US and Canada) is dedicated to using the power of leading-edge science to save and improve lives around the world. Rest assured, your horses are receiving the best possible disease protection. Let's look at the differences between these two medications, as well as some other treatment options for your dog's allergies. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. 11. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. Her asthma had gotten so bad I thought I wouldnt be able to ride her again, but now we are back to w-t-c. She is down to every other day. 19. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. Rosenkrantz WS, Bourgeois AS. Once you have the horse's symptoms under control, you can try re-introducing hay. She added, "Studies show that omega-3 fatty acids help horses with equine asthma. Her lifelong love of horses motivated her to adopt her college care horse, Claire, upon graduation. Im hopeful, however, that I will be able to stretch out more so that Im looking at $250 across 8-10 weeks instead. The powerful network of cells and antibodies known as the immune system can recognize dangerous invaders and disarm them before they hurt the host. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. Left untreated, these conditions can not only cause discomfort but also lead to raw, broken skin that allows bacteria to invade and infect. This site is for US animal healthcare professionals. Both can be very serious. Serious side effects include seizures, abnormal breathing, incoordination, muscle tremors, and coma. Ordering patient medications is easy. . 18. The drug is primarily used as a tranquilizer to calm anxious pets, especially dogs and horses, according to DailyMed. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. Six adult horses with a mean weight of 528 kg were . But you're making a deal with the devil when you use these . Apoquel is a dog allergy medicine used to treat and control chronic manifestations of allergic and atopic dermatitis in dogs. Yes, we looked into this approach, but unfortunately it was not a viable option for my horse for a variety of reasons including other health factors and severity of allergies. Many medications are available to help manage your horses allergies, some of which are best used as preventives in sensitive horses. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. APQ-01043R3, halved to ensure that the ingredients are equally distributed. K. Route of Administration . She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982. J Zoo Wildl Med 2017;48(3):818-828. Search term . Thereafter the dose should be reduced to once daily for maintenance. Milder cases of asthma are still associated with coughing, airway inflammation, mucous production, and poor performance.. Stay on top of the most recent Horse Health news with, If interested in adopting this horse, please submit an Adoption Inquiry via our website: Allaboutequine dot org. There are a few medication protocols for horses with Equine Asthma. 4. Oclacitinib maleate is used twice daily for two weeks and then dropped to a maintenance dose of once daily. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. Every cough means something is a common saying among equine veterinarians. Lopes NL, Campos DR, Machado MA, et al. Ortalda C, Noli C, Colombo S, et al. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Hay naturally contains microscopic fungal spores, plus bacterial and dust components that horses inhale as they eat, explains Lisa Fultz, DVM, MS, Dipl. However, the twice-daily use must not last for more than 14 days. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. Speak to yourveterinarian in an emergency. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production. We have been using an inflatable fleece e-collar on her . 14. Pruritus is a common clinical sign in allergic skin diseases. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. 6. Have you considered trying allergy testing? I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. 6. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 - 0.27 mg/lb. So I want to make sure she has the support she needs to acclimate to hot humid summer weather. 2: The Barn and Pasture: Horses with Summer-Pasture-Associated disease usually have less symptoms when kept in the barn during the warmer months. KER offers EO3, which contains the omega-3 fatty acids DHA and EPA. Webcast | APOQUEL tablets may be administered with or without food. Some states restrict the information we may provide about controlled substances. 7. 25. Topics. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. If you must give corticosteroids to an asthmatic horse, your veterinarian might prescribe them to be administered via an aerosol route through the nostril (rather than orally or via injection), which minimizes the amount that gets into the general circulation. Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. Cost is <$50/month, its easy, and its usually very effective. Its expensive, but its working. In fact, in our recent study evaluating almost 400 potential allergens, latex proteins were the most significant allergens for diagnosing severe equine asthma.. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea. You'd do anything for your pet. For years, glucocorticoids and cyclosporine have been used for the symptomatic management of atopic dermatitis, including the associated pruritus. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. Cost for the initial course of treatment (about 12 days) will be around $300-400. Apoquel. to 14 days, and then administered once daily for maintenance therapy. The dose range is very strict, I do not recommend going above the recommended dose due to immune suppression, below the range and it doesn't seem to work in most cases. Apoquel Dosage for Dogs. Side effects have been rarely seen and documented, but the most common occurrences have been mild vomiting and diarrhea. I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. BMC Vet Res 2019;15(1):137. J Biol Chem 2007;282(28):20059-20063. The concentration of the drug is 500 mg/ml. These can be severe and lead to a life-threatening, airway-blocking, whole-body reaction called anaphylaxis. This makes it a common site for the bodys expression of allergic reactions. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. The recommended dose of Apoquel for dogs is 0.18 to 0.27 mg per pound of body weight. The only FDA-approved equine PSGAG. This includes dietary supplements, shampoos, liniments, fly sprays, coat conditioners, etc. This is interesting. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. Apoquel Oclacitinib Used for Pet Meds MORE expand_more savings GoodRx lowest price $75.90 (Save -22%) local_offer Avg retail price $62.49 medication Availability Brand only Get 20% off your first order with code GOODRX20 Shop Apoquel at America's #1 Pet Pharmacy for the best pet prescription medications online! Ive used it on a couple of mine, and I also have some friends who have done it. Frank RK, Galvan BA, Schoell AR, et al. Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. She then completed a 1-year rotating small animal internship in Massachusetts followed by a 3-year veterinary dermatology residency in Georgia. 25. Oclacitinib, a Janus kinase inhibitor, has become an important drug in the management of allergic pruritus. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. found a significant improvement in 76% of horses with skin allergies within one year of using allergen-desensitization serums. To ensure that it's easy to administer the proper dosage to your dog, this treatment comes in three different dosages. Summer-pasture-associated horses tend to be triggered by spring/summer allergens like grasses and trees, and classic horses tend to be triggered by barn dust and mold spores. This regimen may work better because oclacitinib has a short half-life of 4 hours. Oclacitinib can be given without food and may be discontinued without tapering. Hay replacement consists of any of the following: a complete pelleted diet, soaked alfalfa cubes, hay pellets, or possibly a bagged forage product like Chaffhaye. There is a new drug available to help allergic horses: Apoquel. 30. I have noticed that in general she is more comfortable on cooler days. Cosgrove SB, Wren JA, Cleaver DM, et al. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. Aymeric E, Bensignor E. A case of presumed autoimmune subepidermal blistering dermatosis treated with oclacitinib. 13. Apoquel has been a game changer, however. Drake GJ, Nuttall T, Lpez J, et al. Since the vast majority of Equine Asthma patients do not have a histamine-associated problem, this isn't likely to work for most. Apoquel can be administered with or without food. In more severe cases, Apoquel can be given twice per day. It is most risky in horses that have metabolic disease like Equine Metabolic Syndrome (insulin resistance), PPID (cushings), or those that are overweight. Apoquel (oclacitinib tablet) Dosing & Administration How to dose Apoquel 0.4-0.6 mg/kg (0.18-0.27 mg/lb) Twice daily (BID) for up to 14 days Continue therapy once daily (SID) thereafter for maintenance May be given with or without food May discontinue without tapering Apoquel Dosing Guide Weight Range (lb) Number of Tablets to be Administered Many allergic reactions are evident as a mild case of transient hives. Allergies are generally managed based on the severity of clinical signs. Typically, a few sessions are required. Vet Dermatol 2017;28(5):485-e113. Apoquel reduces dog itch, and also decreases inflammation, redness, or swelling of the skinso your dog feels better as quickly as possible What is Apoquel Tablet? The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. For this first stretch, thats not going to get me too far since I need the loading dose up front. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Currently, White is part of a team evaluating the possibility of delivering allergy shots in the form of a juice squirted under the horses tongue. Apoquel doses are usually between .04-.06 milligrams per kilogram of body weight (mg/kg) . The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies.